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Pharmaceutical Flow Control for High-Purity Processes

SVF Flow Controls provides high-purity valve and automation solutions for pharmaceutical and biotech processes where cleanliness, drainability, material compatibility, and reliable flow control are critical.

SVF solutions support applications including bioprocessing and fermentation, purified water and Water for Injection systems, formulation and filling, and clean-steam distribution. Product suitability, materials, surface finish, seat compounds, connections, and compliance documentation should be confirmed for the exact valve series and configuration.


WHY PHARMACEUTICAL LEADERS CHOOSE SVF

  • Confidence in Compliance: Designs that meet FDA, USP, and ASME BPE standards.

  • Engineered for Cleanliness: Electropolished finishes and high-purity materials that protect your process.
  • Efficiency & Reliability: Simplified maintenance, consistent performance, and long-term durability.
  • Tailored Solutions: Custom valve configurations and automated assemblies built around your process needs.
  • High-Purity Diaphragm Valves
  • Tri-Clamp and Tube-End Sanitary Valves
  • Actuated Control Systems for Process Automation


CleanFLOW High-Purity Valve Solutions  

SVF’s CleanFLOW product family includes two-way, multi-port, specialty-alloy, fire-safe, and clean-steam valve options for pharmaceutical and biotech process systems.

SB7 CleanFLOW High-Purity Ball Valve

The SB7 is a three-piece, 316L stainless steel high-purity ball valve available in sizes from 1/2 inch through 6 inches. Its Tube-ID, drainable design follows ASME BPE guidelines, its standard interior finish is 15 Ra or better, and its ISO 5211 mounting pad supports valve automation. SVF states that the materials used in the SB7 comply with FDA, USDA, and 3-A requirements.

SB7F CleanFLOW Forged Ball Valve

The SB7F provides a forged high-purity option for pharmaceutical and biotech applications. It is available in sizes from 1/2 inch through 4 inches and includes a Tube-ID drainable design, Tri-Clamp and Extended Tube O.D. connections, encapsulated body seals, and an ISO 5211 direct-mount automation pad. Its standard TFM1600 seat material complies with 21 CFR 177.1550.

TSB7 and TSB7F Multi-Port CleanFLOW Ball Valves

The TSB7 and TSB7F provide multi-port high-purity flow control for pharmaceutical and biotech systems. Both series are available in sizes from 1/2 inch through 4 inches and offer ASME BPE-compliant Tube-ID designs, Tri-Clamp and Extended Tube O.D. connections, ISO 5211 automation mounting, and side-port or bottom-port configurations. The TSB7F adds forged 316L stainless steel construction and a standard interior finish of 20 Ra or better.

SB79 CleanFLOW Hastelloy Ball Valve

The SB79 provides a Hastelloy CleanFLOW option for pharmaceutical, biotech, and specialty chemical applications. It includes a drainable Tube-ID design, Tri-Clamp and Extended Tube O.D. connections, orbital-welding-compatible extended ends, and an ISO 5211 automation mounting pad.

Opus Clean Steam Trap Test Valve

The Opus is designed specifically for high-purity pharmaceutical clean-steam systems. It provides three states of fluid control and uses Tube-ID porting designed around ASME BPE guidelines for full flow, drainability, surface finish, and materials. Available material options include 316L stainless steel, Hastelloy, and AL6XN.

 

Hygienic Design, Drainability, and Cleanability

CleanFLOW valves use Tube-ID port openings designed to match adjacent process tubing and improve predictable flow, cleanability, and drainability. Product options include sanitary Tri-Clamp connections, extended tube ends for orbital welding, encapsulated body seals, hygienic TFM1600 seats, and optional purge-port configurations for Clean-in-Place and Steam-in-Place processes.

Surface finishes and cleanability features vary by series. Engineers should confirm the required Ra finish, seat material, end connections, purge-port configuration, and supporting documentation for the exact valve being specified.
 

Pharmaceutical Valve Automation

Several CleanFLOW valve series include ISO 5211 mounting pads for direct actuator installation. SVF can configure valve, actuator, and control assemblies for on-off or automated pharmaceutical process applications.

Automation requirements should be evaluated based on the selected valve series, operating conditions, fail position, control signal, cleanroom requirements, and applicable validation procedures.


Technical Documentation and Compliance Review

Individual SVF product pages provide access to specification sheets, data sheets, installation and operating manuals, and other technical documentation. Before selecting a valve, confirm:

  • Body, ball, stem, seat, and seal materials
  • Surface finish
  • Size and connection availability
  • Pressure and temperature limits
  • Drainability and CIP/SIP requirements
  • FDA or other material-compliance statements
  • ASME BPE applicability
  • Automation and control requirements
  • Required material and compliance documentation

Compliance statements should be tied to the exact product series, material, seat compound, size, and configuration rather than applied broadly across every SVF pharmaceutical valve.
 

FAQs

Which SVF valve series are designed for pharmaceutical and biotech applications?

SVF’s pharmaceutical and biotech offering includes the CleanFLOW SB7 and SB7F two-way high-purity ball valves, TSB7 and TSB7F multi-port ball valves, SB79 Hastelloy ball valve, SB7X fire-safe high-purity ball valve, and Opus clean-steam trap test valve. Product selection depends on the process media, flow path, construction material, sanitary connections, cleanability requirements, and automation needs.
 

Do SVF CleanFLOW valves comply with FDA, USP, and ASME BPE requirements?

Compliance varies by valve series, material, seat compound, and configuration. Several CleanFLOW product pages identify ASME BPE-compliant designs, and the SB7 states that its materials comply with FDA, USDA, and 3-A requirements. The SB7F, TSB7, and TSB7F identify TFM1600 seat material that complies with 21 CFR 177.1550. Any FDA, USP, ASME BPE, or other compliance requirement should be confirmed against the documentation for the exact product being specified.
 

Do SVF pharmaceutical valves support CIP and SIP processes?

SVF positions its pharmaceutical valve solutions for CIP and SIP environments. CleanFLOW valves use drainable Tube-ID designs, and certain configurations can include purge ports to support Clean-in-Place or Steam-in-Place processes. Confirm drainability, valve orientation, purge-port requirements, seat materials, temperature limits, and cleaning procedures for the selected series.

What materials, surface finishes, and sanitary connections are available?

Available configurations include cast or forged 316L stainless steel and specialty alloys such as Hastelloy. Depending on the series, options may include interior finishes of 15 Ra or 20 Ra or better, Tri-Clamp connections, Extended Tube O.D. ends, orbital-welding-compatible ends, and hygienic TFM1600 seats. Exact availability should be confirmed on the individual product page and technical sheet.

Can SVF pharmaceutical valves be automated?

Yes. Multiple CleanFLOW valve series include ISO 5211 mounting pads for actuator installation. SVF also offers pneumatic and electric actuators, controls, and configured valve automation packages. The appropriate assembly depends on the valve series, required operating torque, fail position, control method, environmental conditions, and process-validation requirements.
 

Partner with SVF Flow Controls to ensure your pharmaceutical systems meet the highest standards of purity and performance.
Contact Us to learn how our engineered valve solutions can elevate your process.

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